CBLIF

CBLIF, also known as gastric intrinsic factor (IF) or GIF, is a glycoprotein secreted by gastric parietal cells. It specifically binds to dietary vitamin B12, protecting it from degradation in gastric acid and facilitating its absorption in the ileum, which is essential for erythropoiesis and neurological function.
Defects in CBLIF cause congenital intrinsic factor deficiency and pernicious anemia, leading to megaloblastic anemia and cognitive impairment. Current treatment relies on vitamin B12 supplementation. Recombinant CBLIF and absorption-enhancing formulations are under preclinical development to improve oral delivery for patients with malabsorption disorders.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CBLIF Antibody (CSB-PA009417YA01HU)

Validated Data

Western blot
All lanes: CBLIF antibody at 2µg/ml + Mouse stomach tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46, 43 kDa
Observed band size: 46 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009417YA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA009417YA01HU at dilution of 1:100

The following CBLIF reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CBLIF Antibodies

CBLIF Proteins

CBLIF Antibodies

CBLIF Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA009417LA01HU	CBLIF Antibody	Human	ELISA, IHC
CSB-PA009417LD01HU	CBLIF Antibody, Biotin conjugated	Human	ELISA
CSB-PA009417YA01HU	CBLIF Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA009417YD01HU	CBLIF Antibody, Biotin conjugated	Human	ELISA

CBLIF Proteins

CBLIF Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP009417HU	Recombinant Human Cobalamin binding intrinsic factor (CBLIF)	Yeast

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

CBLIF

Popular Product: