CHD7

CHD7 encodes chromodomain-helicase-DNA-binding protein 7, also commonly known as KIAA1167. This protein plays a critical role in chromatin remodeling through its helicase and ATPase activities, which are essential for gene expression regulation. It is involved in the Wnt signaling pathway, contributing to normal development processes.
Mutations in CHD7 are associated with CHARGE syndrome, a complex genetic disorder affecting multiple body systems. In terms of drug development, current research focuses on understanding its detailed mechanism to identify potential therapeutic targets. Although there are no specific drugs targeting CHD7 yet, the progress in this field shows promise for future treatment strategies.