COMMD3

COMMD3, also known as copper metabolism domain containing 3, encodes a protein that is part of the COMMD protein family. This family is characterized by a conserved C - terminal COMM domain. The protein functions mainly in regulating copper homeostasis and can also participate in NF - κB signaling pathway, which is crucial for immune response and cell survival.
Abnormalities in COMMD3 have been associated with certain copper - related metabolic disorders. In drug development, researchers are exploring agents that can modulate the function of COMMD3 to correct copper imbalances and regulate the NF - κB pathway, aiming to treat associated diseases and improve patient outcomes.