DGKD

DGKD, also known as Diacylglycerol Kinase Delta, and by other names such as DAG kinase delta, is a cytoplasmic enzyme encoded by the DGKD gene. It is predominantly expressed in tissues such as the heart, skeletal muscle, and testis. The mechanism of action for DGKD involves phosphorylating diacylglycerol (DAG) to produce phosphatidic acid (PA), thereby regulating the concentration of these two lipids as cellular signaling molecules and influencing cellular signaling processes.

DGKD participates in the modulation of multiple cellular physiological processes, including cell proliferation, migration, glucose uptake, immune response, and the construction of neuronal networks. The activity of DGKD is crucial for maintaining the balance of DAG and PA within the cell, which in turn impacts various signaling pathways. Furthermore, dysfunctions in DGKD are associated with certain diseases, potentially playing a role in neurological disorders, cardiovascular diseases, and metabolic disorders, making it a potential target for drug development and disease treatment.