DIF

DIF protein is a transcription factor in Drosophila melanogaster, belonging to the NF-κB protein family. It plays a crucial role in the insect's immune system, participating in the regulation of antimicrobial peptide expression and the transcription of other immune genes. DIF protein regulates the insect's innate immune response by participating in the Toll signaling pathway and other signaling pathways. The structure of DIF protein includes a DNA-binding domain and a transcription activation domain, enabling it to bind to specific DNA sequences and regulate the transcription of downstream genes. Researchers can use Drosophila as a model organism to further understand the working principles of the insect immune system and the mechanisms of immune-related diseases by studying the role of DIF protein in the immune response. This contributes to the development of new immune modulation strategies and treatment methods.

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Recombinant Drosophila melanogaster Dorsal-related immunity factor Dif (Dif), partial