ELOF1

ELOF1, also known as Transcription elongation factor ELOF1, is a small zinc-finger protein that plays a crucial role in transcription elongation and transcription-coupled DNA repair (TCR). It interacts with RNA polymerase II (RNAPII) and promotes efficient transcription elongation. ELOF1 is involved in TCR by facilitating the recruitment of UVSSA and TFIIH to repair transcription-blocking DNA lesions, thereby preventing genome instability. Mutations in ELOF1 are associated with Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2 and Xeroderma Pigmentosum Group B. Research on ELOF1 has led to insights into drug development for diseases involving TCR and DNA repair pathways.
ELOF1's function in transcription elongation and TCR is essential for maintaining genomic stability and preventing diseases such as Cockayne syndrome. Its role in directing RNAPII ubiquitylation and facilitating the assembly of TCR complexes suggests potential therapeutic targets for drug development. Studies on ELOF1's interaction with CRL4CSA and its role in preventing R-loops and protecting against DNA replication stress highlight its significance in both transcriptional and replicative processes.