ERBIN

ERBIN, also known as Erbb2 interacting protein, is a protein involved in various signaling pathways. It acts as a negative regulator by interacting with the ErbB2 receptor, thereby modulating cell proliferation, differentiation, and apoptosis. ERBIN is crucial in the Smad1/5 pathway, where it helps maintain cell structure integrity. This protein is associated with diseases like spinal cord injury, where its overexpression may lead to apoptosis. Research on ERBIN inhibitors has shown potential in treating spinal cord contusions by modulating ERK1/2/MAPK and NF-kB/MAPK pathways, suggesting its role in drug development for neurological disorders.

Popular Product:

ERBIN Antibody (CSB-PA857021ESR1HU)

Validated Data

Western blot
All lanes: VSX1 antibody IgG at 0.87μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 159, 154, 153, 152, 151, 147, 160 kDa
Observed band size: 159 kDa

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA857021ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA857021ESR1HU at dilution of 1:100

The following ERBIN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ERBIN Antibodies

ERBIN Proteins

ERBIN Antibodies

ERBIN Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA000521	Phospho-ERBB2IP (Y1104) Antibody	Human	WB, ELISA
CSB-PA857021ESR1HU	ERBIN Antibody	Human	ELISA, WB, IHC
CSB-PA857021ESR2HU	ERBIN Antibody	Human	ELISA, IHC

ERBIN Proteins

ERBIN Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP770455MO CSB-EP770455MO CSB-BP770455MO CSB-MP770455MO CSB-EP770455MO-B	Recombinant Mouse Protein LAP2 (Erbb2ip), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ERBIN Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP857021HU CSB-EP857021HU CSB-BP857021HU CSB-MP857021HU CSB-EP857021HU-B	Recombinant Human Protein LAP2 (ERBB2IP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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