General transcription and DNA repair factor IIH helicase subunit XPD is a protein in humans that is encoded by ERCC2 gene. ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.

ERCC2 Antibodies

ERCC2 Antibodies for Homo sapiens (Human)

ERCC2 Proteins

ERCC2 Proteins for Homo sapiens (Human)

ERCC2 Proteins for Bos taurus (Bovine)

ERCC2 Proteins for Mus musculus (Mouse)

ERCC2 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)


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