DNA excision repair protein ERCC-6 is a protein in humans that is encoded by ERCC6 gene. Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
The following ERCC6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ERCC6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007774GA01HU | ERCC6 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA008134 | ERCC6 Antibody |
Human | IHC, ELISA |
ERCC6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP007774HU CSB-EP007774HU CSB-BP007774HU CSB-MP007774HU CSB-EP007774HU-B |
Recombinant Human DNA excision repair protein ERCC-6 (ERCC6), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |