DNA excision repair protein ERCC-6 is a protein in humans that is encoded by ERCC6 gene. Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
ERCC6 Antibodies for Homo sapiens (Human)
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ERCC6 Proteins for Homo sapiens (Human)
In Vivo Biotinylation in E.coli