EVA1B

EVA1B, or Eva-1 homolog B (also known as TMEM166 or FAM176B), is a transmembrane protein critical for autophagy regulation. It interacts with core autophagic components like LC3 and Beclin-1 to facilitate autophagosome formation, a key step in degrading damaged cellular components.
Dysregulated EVA1B links to the PI3K/Akt/mTOR pathway, a central autophagy modulator. Its abnormal expression correlates with neurodegenerative diseases (e.g., Alzheimer’s, where impaired autophagy drives amyloid-beta buildup) and cancers (e.g., colorectal cancer, where downregulation enhances tumor progression). No targeted drugs are approved yet, but preclinical studies explore EVA1B modulation as a potential autophagy-based therapy.