Function
(From Uniprot) |
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
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| Gene References into Functions |
- Report dysregulation of the Fas/FasL system occurs in an experimental animal model of HELLP syndrome. PMID: 28501275
- Vitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in diabetic cardiomyopathy rats, which might be used as a potential effective therapy for the disease. PMID: 28595623
- Study found that propofol anesthesia activates Fas/FasL-mediated extrinsic and Bcl-2-dependent intrinsic apoptotic pathways, resulting in caspase-8 and caspase-9 activations, respectively, and established upregulation of caspase-1 and IL-1beta cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood. PMID: 27189477
- NaIO3 activates Fas-mediated cell death, both in the RPE and photoreceptor, and that a small peptide antagonist of the Fas receptor, Met12, significantly reduces the extent of this cell death. PMID: 28346613
- Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14. PMID: 27561622
- miR-133b-5p might play a particularly important role in the cardioprotective effect of morphine preconditioning by regulating the target gene Fas PMID: 27919821
- Organic pollutants in drinking water impair liver function, with the involvement of Fas and mitochondria-mediated apoptosis in rats. PMID: 26316710
- Mip1 over-expression inhibited H2O2-induced apoptosis and upregulation of Fas induced by H2O2 in H9c2 myogenic cells. PMID: 25310648
- Chronic methamphetamine exposure will activate cardiac Fas-dependent and mitochondria-dependent apoptotic pathways. PMID: 24307234
- Fas protein was up-regulated in rat mesangial cells, and its neutralizing antibody ZB4 partly inhibited M2 macrophage-induced apoptosis PMID: 23973665
- The expression of Fas in spermatogenic cells and the sperm aberration of each fluorotic group were higher than control group. PMID: 20568470
- Autophagy activation occurs in photoreceptors after retina-retinal pigment epithelium separation. This appears to be, at least in part, dependent on Fas receptor activation and plays role in regulating level of photoreceptor apoptosis. PMID: 21421874
- The treatment with cefoperazone sodium and levofloxacin lactate could inhibit the expression of Fas and Bax and enhance the expression of Bcl-2 in rats infected with Vibrio vulnificus. PMID: 19399403
- Inhibition of Fas can diminish LPS-induced apoptosis and inflammatory cytokine production in type II alveolar epithelial cell. PMID: 19823951
- increased expression on conjunctival epithelial cells of patients with cystic fibrosis PMID: 19642903
- Aluminium could influence the activities of learning and memory and could reduce the expression of Bcl-2 and promote the expression of Fas. PMID: 19267062
- Results indicate that cytokine-treated beta-cells may possess two pools of Fas protein, one of which is inducible by cytokines and accounts for surface Fas expression, and one which is constitutively expressed in cytoplasmic compartments. PMID: 12683940
- critical tyrosine residues of CD95 are targets of the anti-apoptotic action of nitric oxide PMID: 14679192
- CD95 regulation involves complex phosphorylations with CD95-tyrosine phosphorylation favoring CD95 membrane trafficking and DISC formation, whereas CD95 Ser/Thr phosphorylation inhibits these processes. PMID: 14699504
- epidermal growth factor receptor and CD95 activation are triggered by Src family kinase Yes PMID: 15039424
- FAS-mediated apoptosis pathway becomes activated and transcriptionally upregulated after retinal detachment. The peak of FAS activation precedes that of the intrinsic pathway, and inhibition of FAS activation can decrease caspase-9 activity. PMID: 15557468
- Adult spinal motor neuron apoptosis is mediated by upstream NO and ONOO- genotoxicity and downstream p53 and Fas activation and is shifted to necrosis by mutant SOD1. PMID: 16000635
- In rat islets, constitutive expression of Fas ligand and glucose-induced Fas receptor expression were observed only in 7- to 8-month-old but not in 2- to 3-month-old islets PMID: 16936193
- Activation of glial cells and upregulation of Fas suggest that glial cells may contribute to Fas-mediated cell death in the neurodegeneration process of chronic ocular hypertensive retinal insult. PMID: 17045251
- Data strongly suggests that transcriptional up regulation of Fas could predispose a group of spermatocytes to Fas ligand triggering apoptosis by the extrinsic and intrinsic pathway. PMID: 17195944
- These results suggest that Hsp70 is capable of protecting the cardiomyocyte from stress-induced injury by inhibiting Fas-mediated apoptosis. PMID: 17441510
- Apoptosis in our model occurs via both extrinsic and intrinsic pathways, and activation of Fas may play a role. PMID: 18289516
- CDK inhibitors suppress MDM2 levels and enhance p53 expression that facilitates bile acid-induced, ceramide-dependent CD95 activation to induce both apoptosis and autophagy in primary hepatocytes PMID: 18614532
- Using single-particle EM, we have identified a near continuum of conformations consistent with a remarkable flexibility of FAS. PMID: 19151726
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