FOXP3

Forkhead box protein P3 is a protein in humans that is encoded by FOXP3 gene. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.

FOXP3 Antibodies

FOXP3 Antibodies for Human

FOXP3 Antibodies for Homo sapiens (Human)

FOXP3 Proteins

FOXP3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

FOXP3 Proteins for Mus musculus (Mouse)

FOXP3 Proteins for Homo sapiens (Human)

FOXP3 ELISA Kit

FOXP3 ELISA Kit for Homo sapiens (Human)

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