FOXP3

FOXP3 encodes the forkhead box P3 protein, also commonly known as scurfin. This protein serves as a crucial transcription factor that plays a vital role in the development and function of regulatory T - cells (Tregs). It acts by binding to specific DNA sequences and modulating the expression of genes involved in immune responses. FOXP3 is mainly involved in the transforming growth factor - beta (TGF - β) signaling pathway.
Defects in the FOXP3 gene are linked to immune - related diseases such as immune dysregulation, polyendocrinopathy, enteropathy, X - linked (IPEX) syndrome. In drug development, efforts are underway to target FOXP3 - related pathways. Some experimental therapies aim to enhance or suppress FOXP3 activity, with the hope of treating various autoimmune and inflammatory conditions.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FOXP3 Antibody (CSB-PA15229A0Rb)

Validated Data

Western Blot
Positive WB detected in: Mouse thymus tissue
All lanes: FOXP3 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 48, 44, 50, 45 kDa
Observed band size: 48 kDa

Immunohistochemistry of paraffin-embedded Hela cells using CSB-PA15229A0Rb at dilution of 1:100

The following FOXP3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

FOXP3 Antibodies

FOXP3 Proteins

FOXP3 Antibodies

FOXP3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA15229A0Rb	FOXP3 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA15229C0Rb	FOXP3 Antibody, FITC conjugated	Human
CSB-PA15229B0Rb	FOXP3 Antibody, HRP conjugated	Human	ELISA
CSB-PA15229D0Rb	FOXP3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA005784	FOXP3 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA999916	FOXP3 Antibody	Human,Mouse	ELISA,WB

FOXP3 Proteins

FOXP3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP764912MOV CSB-EP764912MOV CSB-BP764912MOV CSB-MP764912MOV CSB-EP764912MOV-B	Recombinant Macaca fascicularis Forkhead box protein P3 (FOXP3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FOXP3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP857473MO CSB-BP857473MO CSB-MP857473MO CSB-EP857473MO-B	Recombinant Mouse Forkhead box protein P3 (Foxp3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FOXP3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP861191HU CSB-BP861191HU CSB-MP861191HU CSB-EP861191HU-B	Recombinant Human Forkhead box protein P3 (FOXP3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP861191HU1	Recombinant Human Forkhead box protein P3 (FOXP3), partial	E.coli
CSB-EP861191HU	Recombinant Human Forkhead box protein P3 (FOXP3)	E.coli

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FOXP3

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