FZD5

FZD5 encodes Frizzled-5 protein, also known as Fz-5. It belongs to the Frizzled family of G protein-coupled receptors. Frizzled-5 plays a crucial role in the Wnt signaling pathway, a key regulator of cellular processes such as proliferation, differentiation, and stem cell maintenance. It binds to Wnt ligands, triggering downstream signaling cascades.
Aberrations in FZD5 - related signaling have been associated with multiple diseases, including certain types of cancer and developmental disorders. In drug development, targeting FZD5 and related pathways is under active investigation. Some research is exploring small - molecule inhibitors and monoclonal antibodies to modulate its activity for therapeutic purposes.