GSDMA

GSDMA is a member of the Gasdermin family and is mainly associated with the process of pyroptosis. It consists of several exons and encodes a protein with cytoplasmic localization that can cause cell membrane perforation after activation. The function of GSDMA involves the inflammasome pathway, in which the activation of the inflammasome leads to the activation of caspase-1, which then cleaves GSDMA, releasing its N-terminal domain and triggering pyroptosis. In addition, the activation of GSDMA is also associated with caspase-3, which can promote the process of pyroptosis. GSDMA also plays a role in tumor development and therapeutic response, and its activation may inhibit tumor cell proliferation and shrink tumors. Therefore, the signaling pathways involved in GSDMA are mainly the inflammasome pathway and the cell death pathway. Its research can help to further understand the molecular mechanisms of inflammatory diseases and tumors, and provide possible targets for the development of new therapeutic strategies. By regulating the activation of GSDMA or its role in the signaling pathway, it may help to control inflammatory processes or inhibit tumor growth.