GSDME

GSDME, with its aliases DFNA5 and ICERE-1, originates from human cells and possesses the unique ability to perforate cell membranes. Typically inactive, GSDME is activated upon cleavage by Caspase 3, initiating a localized form of apoptosis known as focal apoptosis. This protein plays a significant role in the pathogenesis of neurodegenerative diseases and the regulation of inflammatory responses, making it a potential therapeutic target for cancer immunotherapy. The ongoing research into GSDME provides valuable insights into the mechanisms of cell death and offers new approaches for developing treatments for a range of diseases, including neurodegenerative disorders and cancer.