General transcription factor IIH subunit 3 is a protein in humans that is encoded by GTF2H3 gene. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
The following GTF2H3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GTF2H3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP619794HU CSB-EP619794HU CSB-BP619794HU CSB-MP619794HU CSB-EP619794HU-B |
Recombinant Human General transcription factor IIH subunit 3 (GTF2H3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H3 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP690889RA CSB-EP690889RA CSB-BP690889RA CSB-MP690889RA CSB-EP690889RA-B |
Recombinant Rat General transcription factor IIH subunit 3 (Gtf2h3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H3 Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP801192DKK CSB-EP801192DKK CSB-BP801192DKK CSB-MP801192DKK CSB-EP801192DKK-B |
Recombinant Dictyostelium discoideum General transcription factor IIH subunit 3 (gtf2h3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GTF2H3 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP837710MO CSB-EP837710MO CSB-BP837710MO CSB-MP837710MO CSB-EP837710MO-B |
Recombinant Mouse General transcription factor IIH subunit 3 (Gtf2h3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |