GTF2H3 Research Reagents

General transcription factor IIH subunit 3 is a protein in humans that is encoded by GTF2H3 gene. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

The following GTF2H3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GTF2H3 Proteins

GTF2H3 Proteins for Homo sapiens (Human)

GTF2H3 Proteins for Rattus norvegicus (Rat)

GTF2H3 Proteins for Dictyostelium discoideum (Slime mold)

GTF2H3 Proteins for Mus musculus (Mouse)

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