GTF2H4

The protein encoded by GTF2H4 is general transcription factor IIH subunit 4, commonly known as p52. It is a core component of the TFIIH complex, which plays critical roles in transcription initiation and nucleotide excision repair. GTF2H4 stabilizes the complex structure and modulates the helicase activity of XPB, facilitating RNA polymerase II transcription and DNA damage repair processes.
Dysregulation of GTF2H4 is linked to xeroderma pigmentosum and Cockayne syndrome, inherited disorders characterized by impaired DNA repair and increased cancer susceptibility. While no specific drugs targeting GTF2H4 are currently approved, research focuses on its role in cancer progression, exploring potential therapeutic strategies that modulate TFIIH function for cancer treatment.