HAUS7

HAUS7, full name HAUS augmin-like complex subunit 7, has major aliases UIP1 and UCHL5IP. As a core augmin complex component, it sustains mitotic spindle assembly and centrosome integrity, and binds DOCK3 to mediate microtubule formation for axon regeneration. It modulates BDNF/TrkB signaling via DOCK3 Y562 phosphorylation, and participates in mitotic cell cycle pathways and meiotic DNA repair to maintain genomic stability.
HAUS7 dysregulation links to gastric cancer, lymphoma and glaucoma, and its deletion causes ovarian insufficiency and congenital vas deferens aplasia. Preclinically, HAUS7 downregulation suppresses lymphoma cell proliferation, making it a novel anti-lymphoma target. It is also a promising therapeutic candidate for glaucoma, with research exploring its modulation to promote retinal ganglion cell axon regeneration.