HPGDS

HPGDS stands for Hematopoietic Prostaglandin D Synthase, also known as L-PGDS or PGDS2. It catalyzes the isomerization of prostaglandin H2 to prostaglandin D2. This protein is mainly involved in the arachidonic acid metabolic pathway. It plays a crucial role in various physiological processes, such as sleep regulation, allergic responses, and inflammation.
Aberrant expression of HPGDS has been associated with several diseases, including allergic rhinitis, asthma, and certain types of cancer. In drug development, HPGDS inhibitors are being investigated for their potential in treating these diseases. Some pre - clinical and clinical trials have shown promising results in reducing inflammation and alleviating symptoms.