KCNMA1 Research Reagents

Calcium-activated potassium channel subunit alpha-1 is a protein in humans that is encoded by KCNMA1 gene. Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

The following KCNMA1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KCNMA1 Antibodies

KCNMA1 Antibodies for Homo sapiens (Human)

KCNMA1 Proteins

KCNMA1 Proteins for Homo sapiens (Human)

KCNMA1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

KCNMA1 Proteins for Bos taurus (Bovine)

KCNMA1 Proteins for Rattus norvegicus (Rat)

KCNMA1 Proteins for Gallus gallus (Chicken)

KCNMA1 Proteins for Xenopus laevis (African clawed frog)

KCNMA1 Proteins for Oryctolagus cuniculus (Rabbit)

KCNMA1 Proteins for Macaca mulatta (Rhesus macaque)

KCNMA1 Proteins for Sus scrofa (Pig)

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