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Kelch-like ECH-associated protein 1 is a protein in humans that is encoded by KEAP1 gene. Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
The following KEAP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
KEAP1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA012147GA01HU | KEAP1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA005148 | KEAP1 Antibody |
Human,Mouse,Rat | WB, ELISA |
| CSB-PA012147LA01HU | KEAP1 Antibody |
Human, Mouse | ELISA, WB, IHC |
| CSB-PA012147LC01HU | KEAP1 Antibody, FITC conjugated |
Human | |
| CSB-PA012147LD01HU | KEAP1 Antibody, Biotin conjugated |
Human | ELISA |
| CSB-PA247380 | KEAP1 Antibody |
Human,Mouse,Rat | ELISA,IHC |
| CSB-PA011976 | KEAP1 Antibody |
Human,Mouse,Rat | ELISA,IHC |
KEAP1 Antibodies for Mus musculus (Mouse)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA012147LA01MO | Keap1 Antibody |
Mouse, Human | ELISA, WB |
| CSB-PA012147LD01MO | Keap1 Antibody, Biotin conjugated |
Mouse | ELISA |
| CSB-PA012147LB01MO | Keap1 Antibody, HRP conjugated |
Mouse | ELISA |
| CSB-PA012147ZA01MO | Keap1 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
KEAP1 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP012147RA CSB-EP012147RA CSB-BP012147RA CSB-MP012147RA CSB-EP012147RA-B |
Recombinant Rat Kelch-like ECH-associated protein 1(Keap1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KEAP1 Proteins for Sus scrofa (Pig)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP012147PI CSB-EP012147PI CSB-BP012147PI CSB-MP012147PI CSB-EP012147PI-B |
Recombinant Pig Kelch-like ECH-associated protein 1(KEAP1) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KEAP1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP012147PYX CSB-EP012147PYX CSB-BP012147PYX CSB-MP012147PYX CSB-EP012147PYX-B |
Recombinant Pongo abelii Kelch-like ECH-associated protein 1(KEAP1) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KEAP1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP012147MO CSB-BP012147MO CSB-MP012147MO CSB-EP012147MO-B |
Recombinant Mouse Kelch-like ECH-associated protein 1(Keap1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012147MO | Recombinant Mouse Kelch-like ECH-associated protein 1(Keap1) |
E.coli |
KEAP1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP012147HU | Recombinant Human Kelch-like ECH-associated protein 1(KEAP1) |
Yeast |
| CSB-BP012147HU CSB-MP012147HU CSB-EP012147HU-B |
Recombinant Human Kelch-like ECH-associated protein 1(KEAP1) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KEAP1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL012147HU | Human Kelch-like ECH-associated protein 1(KEAP1) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
KEAP1 ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL012147MO | Mouse Kelch-like ECH-associated protein 1(KEAP1) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 1.17 pg/mL |
