KEAP1

KEAP1, identified as Kelch-like ECH-related protein 1 or IKBKE inhibitor, is a cytoplasmically active protein encoded by the KEAP1 gene. It interacts with the NRF2 protein, facilitating its ubiquitination and subsequent proteasomal degradation, which in turn suppresses NRF2's role in antioxidant response and metabolic gene regulation. Aberrant KEAP1 function is linked to a spectrum of diseases, particularly various forms of cancer, where mutations or misexpression can lead to hyperactivation of the NRF2 pathway, influencing tumor cell metabolism and survival, making the KEAP1-NRF2 axis a promising target for oncological therapies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KEAP1 Antibody (CSB-PA012147LA01HU)

Validated Data

Western blot
All lanes: KEAP1 antibody at 2µg/ml
Lane 1: Mouse kidney tissue
Lane 2: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012147LA01HU at dilution of 1:100

Human Kelch-like ECH-associated protein 1(KEAP1) ELISA kit (CSB-EL012147HU)

Validated Data

Code: CSB-EL012147HU

Size: 96T,5×96T,10×96T

Sensitivity: 6.25 pg/mL

Detection Range: 25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following KEAP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KEAP1 Antibodies

KEAP1 Proteins

KEAP1 ELISA Kits

KEAP1 Antibodies

KEAP1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA012147GA01HU	KEAP1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA005148	KEAP1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA012147LA01HU	KEAP1 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA012147LC01HU	KEAP1 Antibody, FITC conjugated	Human
CSB-PA012147LD01HU	KEAP1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA247380	KEAP1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA011976	KEAP1 Antibody	Human,Mouse,Rat	ELISA,IHC

KEAP1 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA012147LA01MO	Keap1 Antibody	Mouse, Human	ELISA, WB
CSB-PA012147LD01MO	Keap1 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA012147LB01MO	Keap1 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA012147ZA01MO	Keap1 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

KEAP1 Proteins

KEAP1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP012147RA CSB-EP012147RA CSB-BP012147RA CSB-MP012147RA CSB-EP012147RA-B	Recombinant Rat Kelch-like ECH-associated protein 1 (Keap1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KEAP1 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP012147PI CSB-EP012147PI CSB-BP012147PI CSB-MP012147PI CSB-EP012147PI-B	Recombinant Pig Kelch-like ECH-associated protein 1 (KEAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KEAP1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP012147PYX CSB-EP012147PYX CSB-BP012147PYX CSB-MP012147PYX CSB-EP012147PYX-B	Recombinant Pongo abelii Kelch-like ECH-associated protein 1 (KEAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KEAP1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP012147MO CSB-BP012147MO CSB-MP012147MO CSB-EP012147MO-B	Recombinant Mouse Kelch-like ECH-associated protein 1 (Keap1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012147MO	Recombinant Mouse Kelch-like ECH-associated protein 1 (Keap1)	E.coli

KEAP1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP012147HU	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1)	Yeast
CSB-BP012147HU CSB-MP012147HU	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1)	Baculovirus Mammalian cell
CSB-EP012147HU	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1)	E.coli
CSB-EP012147HU1	Recombinant HumanKelch-like ECH-associated protein 1 (KEAP1), partial	E.coli
CSB-EP012147HU-B	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1), Biotinylated	E.coli

KEAP1 ELISA Kit

KEAP1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL012147HU	Human Kelch-like ECH-associated protein 1(KEAP1) ELISA kit	serum, plasma, tissue homogenates, cell lysates	6.25 pg/mL

KEAP1 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-EL012147MO	Mouse Kelch-like ECH-associated protein 1(KEAP1) ELISA kit	serum, plasma, tissue homogenates, cell lysates	1.17 pg/mL

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KEAP1

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