L1RE1

The L1RE1 gene encodes the LINE1 retrotransposable element ORF1 protein, also known as L1RE1 or L1ORF1. This protein functions as a nucleic acid chaperone, essential for the retrotransposition of LINE1 elements in the genome. It forms trimeric complexes that bind RNA and facilitate the process of retrotransposition. The ORF1 protein is involved in various cellular processes, including DNA repair and transcriptional regulation. It is associated with several diseases, such as cancer and neuropsychiatric disorders, and its dysregulation may contribute to disease progression. Research on L1RE1 has led to the development of potential therapeutic strategies, including targeting its retrotransposition activity and modulating its expression levels.