MAP3K1, also known as mitogen-activated protein kinase kinase 1, has alternative names including MEKK1, MEKK, MEKK 1, and SRXY6. MAP3K1 plays a role in various cellular signaling pathways, particularly in the MAPK signaling pathway. MAP3K1 can activate downstream MAP2Ks and MAPKs, transmitting signals through a series of phosphorylation steps to regulate multiple functions such as apoptosis, survival, migration, and differentiation. MAP3K1 is also involved in the ubiquitin-proteasome system, exhibiting E3 ubiquitin ligase activity that promotes the ubiquitination and degradation of specific proteins.
Abnormalities in MAP3K1 function are associated with the development and progression of various cancers, including breast cancer and ovarian cancer, making it a potential target for cancer control.
Phospho-MAP3K1 (Thr1402) Antibody (CSB-PA177236)
Validated Data
Western blot analysis of extracts from JK cells (Lane 2), using MAP3K1 (Phospho-Thr1400) Antibody. The lane on the left is treated with antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using MAP3K1 (Phospho-Thr1400) antibody (left)or the same antibody preincubated with blocking peptide (right).
The following MAP3K1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MAP3K1 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA15289A0Rb | Map3k1 Antibody | Mouse | ELISA |
CSB-PA15289C0Rb | Map3k1 Antibody, FITC conjugated | Mouse |
MAP3K1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA177236 | Phospho-MAP3K1 (Thr1402) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA010176 | Phospho-MAP3K1 (T1402) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA010177 | MAP3K1 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA442614 | MAP3K1 Antibody | Human,Mouse,Rat | WB,ELISA |
MAP3K1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP013417MO CSB-EP013417MO CSB-BP013417MO CSB-MP013417MO CSB-EP013417MO-B |
Recombinant Mouse Mitogen-activated protein kinase kinase kinase 1 (Map3k1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP3K1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP013417RA CSB-EP013417RA CSB-BP013417RA CSB-MP013417RA CSB-EP013417RA-B |
Recombinant Rat Mitogen-activated protein kinase kinase kinase 1 (Map3k1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP3K1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP013417HU CSB-EP013417HU CSB-BP013417HU CSB-MP013417HU CSB-EP013417HU-B |
Recombinant Human Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP013417MO | Recombinant Mouse Mitogen-activated protein kinase kinase kinase 1 (Map3k1), partial | E.coli |