NLK

Serine/threonine-protein kinase NLK is a protein in humans that is encoded by NLK gene. Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway.

NLK Antibodies

NLK Antibodies for Human

NLK Proteins

NLK Proteins for Mus musculus (Mouse)

NLK Proteins for Rattus norvegicus (Rat)

NLK Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

NLK Proteins for Bos taurus (Bovine)

NLK Proteins for Homo sapiens (Human)

NLK cDNA for Rattus norvegicus (Rat)

Code Product Name Vector Accession NO.
CSB-CL015859RA Nlk pUC NM_001191924.1

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.