NR4A3

NR4A3, also known as nuclear receptor subfamily 4, group A, member 3, is a nuclear hormone receptor that plays a crucial role in regulating gene transcription. This protein is involved in various cellular processes, including proliferation, apoptosis, cell metabolism, and DNA repair. NR4A3 functions through the regulation of transcriptional elongation, and its activity is modulated by various signaling pathways, such as the MAPK and Wnt pathways. Aberrant expression of NR4A3 has been associated with several diseases, including acute myeloid leukemia and hepatocellular carcinoma. In the context of drug development, NR4A3 has emerged as a potential therapeutic target, with ongoing research focusing on the identification of small molecule activators and inhibitors to modulate its activity for the treatment of these diseases.