OSMR

OSMR, the oncostatin M receptor beta chain, alias interleukin 31 receptor subunit beta, Oncostatin-M-specific receptor subunit beta (isoform 2), interleukin 31 receptor subunit beta, OSMR variant 1, Oncostatin-M-specific receptor subunit beta (isoform 1), OSMRB, Oncostatin -M-specific receptor beta subunit, etc. It is a cell surface receptor, a member of the IL-6 signaling pathway, encoded by its own gene in human cells.The mechanism of action of OSMR is mainly through binding to Oncostatin M (OSM) and activating its downstream signaling.Binding of OSMR to OSM activates signaling pathways such as JAK/STAT, MAPK, and PI3K, which in turn regulate cell proliferation, differentiation, and survival. The biological significance of OSMR is mainly reflected in its involvement in the regulation of a variety of physiological and pathological processes, including cytokine production, immune response, cell proliferation and apoptosis, etc.

The activation of OSMR promotes the proliferation of fibroblasts, smooth muscle cells, and Kaposi's sarcoma cells, but has an inhibitory effect on the growth of some normal and tumor cell lines. In addition, OSMR is involved in the regulation of cardiac hypertrophy, fibrotic remodeling, and cardiac dysfunction, and aberrant activation of its signaling is associated with the development of chronic inflammation and cardiovascular disease. Therefore, OSMR not only plays an important role in maintaining tissue homeostasis and immune homeostasis, but is also a potential target in drug development, especially in the treatment of tumors, arthritis and cardiovascular diseases.