PIAS4 Research Reagents

E3 SUMO-protein ligase PIAS4 is a protein in humans that is encoded by PIAS4 gene. Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

The following PIAS4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PIAS4 Antibodies

PIAS4 Antibodies for Homo sapiens (Human)

PIAS4 Proteins

PIAS4 Proteins for Homo sapiens (Human)

PIAS4 Proteins for Mus musculus (Mouse)

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