POM121

POM121, full name POM121 transmembrane nucleoporin, has major aliases P145 and POM121A, also referred to as NUP121. As a core nuclear pore complex component, it mediates nucleocytoplasmic transport and modulates PPARγ transcriptional activity by regulating its subcellular shuttling. Its soluble isoform sPOM121 interacts with SMARCA5 to drive promoter transcription and activate WNT/β-catenin signaling, also engaging in RAS-RAF-MEK/ERK pathways.
POM121 dysregulation links to colorectal and prostate cancer, with its overexpression predicting poor tumor prognosis, and it correlates with diabetes and rheumatic fever. Preclinical studies target the POM121-PPARγ and sPOM121/β-catenin axes; combining β-catenin inhibitors like ICG-001 with anti-PD-1 boosts anti-tumor immunity, with its targeted modulators under experimental development for cancer therapy.