RBMS1

RBMS1, or RNA-binding motif single-stranded interacting protein 1, alias YC1, MSSP, SCR2, HCC-4, MSSP-1, MSSP-2, MSSP-3, C2orf12 and so on. It is a protein encoded by the RBMS1 gene in humans and belongs to one of the members of the RNA-binding protein family.The mechanism of action of RBMS1 involves binding single-stranded DNA/RNA with two ribonucleoprotein-common sequences (RNP-CS) containing conserved motifs, RNP1 and RNP2, which were initially described in RNA-binding proteins and are required for DNA binding RBMS1 is involved in a variety of biological processes, including DNA replication, gene transcription, cell cycle progression, and apoptosis.

The biological significance of RBMS1 is very broad, as it is not only involved in the regulation of gene expression, but is also associated with tumor immune escape, cell metastasis, and tumor suppression processes. For example, in triple-negative breast cancer, down-regulation of RBMS1 can block the PD-L1 immune checkpoint and promote anti-tumor immunity . In non-small cell lung cancer, RBMS1 interacts with the m6A reader YTHDF1 to promote S100P translation and accelerate cancer cell metastasis . In addition, RBMS1 regulates iron death in lung cancer by modulating the translational control of SLC7A11 . These studies suggest that RBMS1 plays an important role in tumor development and metastasis and is a potential target in tumor therapy.