RBPMS2

RBPMS2 encodes RNA-binding protein with multiple splicing 2, a member of the RBPMS family. It regulates mRNA stability and splicing through binding to target transcripts, often interacting with 3' untranslated regions. Key signaling pathways include TGF-β and Wnt, where it modulates epithelial-mesenchymal transition by controlling downstream gene expression.
Aberrant RBPMS2 expression is linked to colorectal and pancreatic cancers, with downregulation promoting tumor invasion. Preclinical studies investigate its role as a diagnostic biomarker and therapeutic target, focusing on small molecules that restore its tumor-suppressive functions. Current research explores RNA-based strategies to modulate its activity in malignant contexts.