RGS17

RGS17, or regulatory G protein signal 17, is a member of the regulatory G protein signals (RGS) family, encoded by the human RGS17 gene. This protein carries a conserved RGS domain that modulates G protein signals by enhancing the GTPase activity of G protein α subunits, with particular influence over Gαi/o, Gαz, and Gαq pathways. RGS17 is prominently expressed in various tissues, notably in the brain, where it regulates G protein-coupled receptor (GPCR) signaling by hastening the hydrolysis of GTP on G protein α subunits, effectively terminating the signal. Its expression levels have clinical implications; increased RGS17 supports the progression of certain prostate and lung cancers, while decreased expression in ovarian cancer can lead to chemoresistance, positioning RGS17 as a potential therapeutic target in tumor.