RNASEH1 (Ribonuclease H1) is an endonuclease enzyme that specifically cleaves RNA within RNA-DNA hybrids. Its primary function lies in DNA repair processes, particularly in the cleavage of RNA-DNA hybrids. It contributes to maintaining genome stability by eliminating RNA-DNA hybrids, preventing the accumulation of unnecessary hybrid structures, and preserving normal cellular function. Studies indicate that mutations or defects in RNASEH1 are associated with a rare genetic neurodegenerative disorder called Aicardi-Goutières Syndrome (AGS). AGS often presents with neurological and immune system abnormalities, and abnormalities in RNASEH1 might be linked to the appearance of such symptoms. Furthermore, RNASEH1 holds significant potential in cellular biology research and the field of RNA-DNA hybridization. In-depth research on RNASEH1 not only aids in understanding nucleic acid metabolism within cells and maintaining genome stability but also potentially offers new therapeutic approaches or interventions for treating related diseases.
Recombinant Human Ribonuclease H1 (RNASEH1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019801HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RNASEH1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019801HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RNASEH1.
The following RNASEH1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RNASEH1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019801GA01HU | RNASEH1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA019801LA01HU | RNASEH1 Antibody |
Human | ELISA, WB, IHC |
CSB-PA019801LB01HU | RNASEH1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA019801LC01HU | RNASEH1 Antibody, FITC conjugated |
Human | |
CSB-PA019801LD01HU | RNASEH1 Antibody, Biotin conjugated |
Human | ELISA |
RNASEH1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP019801MO CSB-EP019801MO CSB-BP019801MO CSB-MP019801MO CSB-EP019801MO-B |
Recombinant Mouse Ribonuclease H1 (Rnaseh1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RNASEH1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP019801HU CSB-BP019801HU CSB-MP019801HU CSB-EP019801HU-B |
Recombinant Human Ribonuclease H1 (RNASEH1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP019801HU | Recombinant Human Ribonuclease H1 (RNASEH1) |
E.coli |