RNF214

The RNF214 gene encodes a protein known as RNF214 ubiquitin ligase. Commonly referred to as RNF214, this protein plays a crucial role in the regulation of cell cycle and apoptosis. It functions by targeting specific substrates for ubiquitination, thereby modulating signaling pathways. RNF214 is involved in the Hippo signaling pathway, where it promotes the transactivation of downstream genes. The protein has been linked to breast liposarcoma and breast rhabdomyosarcoma, and its dysregulation may contribute to oncogenic progression. In terms of drug development, research is ongoing to identify small molecule inhibitors that can modulate RNF214 activity for therapeutic purposes.