SAV1

Protein salvador homolog 1 is a protein in humans that is encoded by SAV1 gene. Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.

SAV1 Antibodies

SAV1 Antibodies for Homo sapiens (Human)

SAV1 Antibodies for Human

SAV1 Proteins

SAV1 Proteins for Rattus norvegicus (Rat)

SAV1 Proteins for Mus musculus (Mouse)

SAV1 Proteins for Homo sapiens (Human)

SAV1 cDNA for Rattus norvegicus (Rat)

Code Product Name Vector Accession NO.
CSB-CL020722RA Sav1 pUC NM_001097581.1

SAV1 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL851839MO Sav1 pUC NM_022028.2

SAV1 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL875672HU1 SAV1 pUC NM_021818.3

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