SAV1

Protein salvador homolog 1 is a protein in humans that is encoded by SAV1 gene. Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.

SAV1 Antibodies

SAV1 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA020722GA01HU SAV1 Antibody Human,Mouse,Rat ELISA,IHC

SAV1 Antibodies for Human

Code Product Name Species Reactivity Application
CSB-PA875672ESR1HU SAV1 Antibody Human ELISA, WB, IHC, IF
CSB-PA875672ESR2HU SAV1 Antibody Human, Mouse ELISA, WB, IHC, IF, IP

SAV1 Proteins

SAV1 Proteins for Rattus norvegicus (Rat)

Code Product Name Source
CSB-YP020722RA Recombinant Rat Protein salvador homolog 1(Sav1),Yeast Yeast
CSB-EP020722RA Recombinant Rat Protein salvador homolog 1(Sav1),Escherichia Coli E.coli
CSB-BP020722RA Recombinant Rat Protein salvador homolog 1(Sav1),Baculovirus Baculovirus
CSB-MP020722RA Recombinant Rat Protein salvador homolog 1(Sav1),Mammalian cell Mammalian cell

SAV1 Proteins for Mus musculus (Mouse)

Code Product Name Source
CSB-YP851839MO Recombinant Mouse Protein salvador homolog 1(Sav1),Yeast Yeast
CSB-EP851839MO Recombinant Mouse Protein salvador homolog 1(Sav1),Escherichia Coli E.coli
CSB-BP851839MO Recombinant Mouse Protein salvador homolog 1(Sav1),Baculovirus Baculovirus
CSB-MP851839MO Recombinant Mouse Protein salvador homolog 1(Sav1),Mammalian cell Mammalian cell

SAV1 Proteins for Homo sapiens (Human)

Code Product Name Source
CSB-YP875672HU Recombinant Human Protein salvador homolog 1(SAV1),Yeast Yeast
CSB-EP875672HU Recombinant Human Protein salvador homolog 1(SAV1),Escherichia Coli E.coli
CSB-BP875672HU Recombinant Human Protein salvador homolog 1(SAV1),Baculovirus Baculovirus
CSB-MP875672HU Recombinant Human Protein salvador homolog 1(SAV1),Mammalian cell Mammalian cell

SAV1 cDNA

SAV1 cDNA for Rattus norvegicus (Rat)

Code Product Name Vector Accession NO.
CSB-CL020722RA Sav1 pUC NM_001097581.1

SAV1 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL851839MO Sav1 pUC NM_022028.2

SAV1 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL875672HU1 SAV1 pUC NM_021818.3

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.