The SCN2A gene primarily encodes the α2 subunit of the sodium channel, which, together with the β subunit, forms a voltage-gated sodium channel. This channel is primarily expressed in the brain and plays a crucial role in the regulation of memory. Mutations in the SCN2A gene have been closely associated with various neurological disorders, including benign familial neonatal epilepsy, infantile epileptic encephalopathy with migrating focal seizures, and Ohtahara syndrome. These mutations can lead to delayed inactivation of the sodium channel, resulting in chronic depolarization of the membrane potential and increased cellular excitability. Ultimately, this may trigger the development of neurological diseases such as epilepsy, intellectual disability, schizophrenia, and autism.
The following SCN2A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SCN2A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA040291 | SCN2A Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-PA040292 | SCN2A Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-PA937791 | SCN2A Antibody |
Human,Rat | ELISA,IHC |
CSB-PA902560 | SCN2A Antibody |
Human,Rat | ELISA,IHC |
SCN2A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP857853HU CSB-EP857853HU CSB-BP857853HU CSB-MP857853HU CSB-EP857853HU-B |
Recombinant Human Sodium channel protein type 2 subunit alpha (SCN2A), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |