SINHCAF

SINHCAF or FAM60A, TERA, is integral to the regulation of gene expression. By interacting with proteins like SIN3A and HDAC1, SINHCAF advances histone deacetylation, which in turn suppresses gene expression. In zebrafish, this protein is crucial for the formation of primordial germ cells (PGCs); its reduction leads to a decreased PGC count and impacts sex determination, while overexpression results in an increased PGC number and a female bias. SINHCAF also plays a role in negatively regulating cell migration as part of the Sin3 complex, which is vital for sustaining the rapid proliferation of embryonic stem cells and avoiding premature differentiation. These functions underscore SINHCAF's significance in cell fate determination and developmental processes.