SLC20A2

SLC20A2, a member of the solute carrier family 20, can be referred to by its alternative names PiT2 or GLVR-2. This gene is located on human chromosome 8 and is responsible for encoding a sodium-dependent phosphate transporter. This transporter is pivotal for the uptake of phosphate by cells and for maintaining phosphate balance within the body. It facilitates the transmembrane movement of inorganic phosphate, thus regulating its levels. Mutations in the SLC20A2 gene have been linked to conditions such as familial idiopathic basal ganglia calcification (IBGC), also known as Fahr disease, underscoring the gene's role in human health. Moreover, SLC20A2 serves as a receptor for certain viral infections, including retroviruses, showcasing its diverse biological functions.