SLC25A45

SLC25A45 encodes solute carrier family 25 member 45, an integral mitochondrial inner membrane protein. As a mitochondrial carrier superfamily member, it mediates metabolite exchange between the matrix and cytosol; its substrate specificity (e.g., flavin adenine dinucleotide) remains under active investigation. No widely accepted aliases exist beyond the gene symbol.
Pathogenic SLC25A45 variants are linked to mitochondrial encephalomyopathies like Leigh syndrome, driven by impaired oxidative phosphorylation from disrupted metabolite transport. Preclinical research explores small-molecule modulators to restore mitochondrial function, though no clinical trials targeting this protein are currently registered.