SOX17

SOX17, also known as SRY-box transcription factor 17, is a member of the SOX (SRY-related HMG-box) family of transcription factors. It plays a crucial role in the regulation of embryonic development and determination of cell fate. SOX17 functions as a transcriptional regulator, often forming protein complexes with other proteins. It is involved in various signaling pathways, including Wnt/β-catenin and Notch, which are critical for cardiovascular development and maintenance of arterial identity. Dysregulation of SOX17 has been associated with several diseases, such as pulmonary arterial hypertension and cancer. Research on SOX17 has led to potential therapeutic targets for drug development, particularly in the context of cardiovascular diseases and cancer treatment.