SPRR2E

SPRR2E, a member of the small proline-rich protein (SPRR) family, is encoded by the SPRR2E gene. Its full name is Small Proline-Rich Protein 2E. As a key player in epidermal differentiation, it participates in forming the cornified envelope—critical for skin barrier function—by cross-linking with proteins like involucrin and loricrin.
Aberrant SPRR2E expression correlates with skin disorders such as psoriasis and ichthyosis, where barrier integrity is impaired. Current research explores its potential as a biomarker for these conditions, though targeted drugs remain in preclinical stages, with no candidates yet entering clinical trials.