STMN2

STMN2, alias SCG10, SCGN10, is a microtubule-associated protein encoded by a human gene and belongs to the phosphoprotein family. STMN2 is expressed in a variety of tissues, with particularly high expression in the brain and adrenal gland.
The mechanism of action of STMN2 involves microtubule dynamics and signaling, and it regulates cell cycle, cell migration, signaling and transporter protein functions by affecting microtubule stability. STMN2 plays a regulatory role in neuronal growth and is thought to be involved in osteogenesis. Decreased expression of STMN2 has been associated with Down syndrome and Alzheimer's disease. Different splice transcript variants of STMN2 have been observed and a pseudogene of this gene is located on the long arm of chromosome 6.STMN2 plays a major role in axon development and repair, promotes microtubule instability necessary for normal axon growth and regeneration, and its expression is strongly regulated by the nuclear trans-responsive DNA binding protein 43 kDa (TDP-43).