SUGP1

SUGP1 (SURP and G-patch domain containing 1), also termed SF4, is a splicing factor that regulates splice site recognition and proofreading within the major spliceosome. It interacts with components like SF3B1 and activates the DHX15 RNA helicase, ensuring the fidelity of pre-mRNA processing .

This protein is a novel regulator of cholesterol metabolism. Genetic variations near SUGP1 are linked to coronary artery disease and plasma LDL cholesterol levels. It modulates cholesterol homeostasis by influencing the alternative splicing and stability of HMGCR transcripts, a key enzyme in cholesterol synthesis .