TGM3

TGM3, also known as Transglutaminase 3, is an enzyme protein. It is commonly referred to as Epidermal Transglutaminase. This protein plays a key role in cross - linking proteins, contributing to the formation of the cornified envelope in the skin. It is involved in the Wnt/β - catenin signaling pathway, which is crucial for cell growth and differentiation.
Abnormalities in TGM3 have been associated with certain skin diseases, such as ichthyosis vulgaris. In terms of drug development, researchers are exploring potential inhibitors or activators to target TGM3 for treating related skin disorders, aiming to regulate its function and improve skin conditions.