TMED10

TMED10, the transmembrane p24 transport protein 10, also known as p23, TMP21, p24d1, S31I125, Tmp-21-I, S31III125, P24(DELTA). TMED10 is encoded by the human TMED10 gene and belongs to the EMP24/GP25L/p24 family, which is a type I membrane protein with a GOLD structural domain.
TMED10 is localized to the plasma membrane and Golgi pool and is involved in vesicular protein transport. In addition, TMED10 is a member of the heterodimeric secretase complex and is able to regulate the γ-secretase activity of the complex without affecting its ε-secretase activity. TMED10 regulates the entry of a series of nonclassical secreted proteins into the endoplasmic reticulum-Golgi intermediate (ERGIC) by forming homo-oligomers, a pathway known as TMED10-channeled nonclassical secretion (THU), which has been shown to be important in the regulation of IL-33 secretion, maintenance of intestinal homeostasis and neurohomeostasis. Mutations in TMED10 have been associated with early-onset familial Alzheimer's disease.