TMEM158

Transmembrane Protein 158 (TMEM158), also known as C11orf15, is a membrane-localized tumor suppressor. It regulates cell proliferation and survival by inhibiting Akt phosphorylation, a key step in the PI3K/Akt signaling pathway—this action curtails uncontrolled cell growth and metastasis. Downregulation of TMEM158 is linked to breast, lung, and colorectal cancers, often associating with poor patient outcomes.
Preclinical research explores TMEM158 as a therapeutic target. Strategies like gene delivery to restore its expression in tumor cells aim to reactivate its suppressive functions. While no TMEM158-targeted drugs are in clinical trials, its role in modulating oncogenic pathways makes it a promising candidate for future anti-cancer therapies.