TRGC2

TRGC2, T cell receptor gamma constant 2, alias TCRGC2, TRGC2(2X), TRGC2(3X). TRGC2 is encoded by the human TRGC2 gene, which is located on chromosome 7 in the region p14.1. TRGC2 is the constant region of the gamma chain of the T-cell receptor (TCR), which along with the variable region of the gamma chain of the TCR, constitutes the TCR that involved in recognizing non-peptide antigens that are often expressed at the epithelial border, implying that most of the antigens that activate γδ T cells are MHC-independent.
TRGC2 plays a role in adaptive immune responses, is predicted to be an integral part of the membrane, is part of the T-cell receptor complex and is active at the outer side of the plasma membrane. TRGC2 is essential for a variety of functions of γδ T cells, including skin and mucosal epithelial damage repair, tolerance induction, cytotoxicity, and production of multiple cytokines that regulate immune responses.

Popular Product:

Recombinant Human T-cell receptor gamma-2 chain C region (TRGC2), partial