USP43

USP43, or Ubiquitin-specific protease 43, is a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease (USP) family. It catalyzes the removal of ubiquitin chains from target proteins, regulating their stability, subcellular localization, and functional activity. USP43 is involved in key cellular processes like cell cycle progression and DNA damage repair, with reported associations with the Wnt/β-catenin signaling pathway.
Dysregulation of USP43 has been linked to human cancers, including colorectal and non-small cell lung cancer, where its overexpression may drive tumor proliferation and metastasis. Preclinical research is ongoing to develop selective small-molecule inhibitors targeting USP43’s catalytic domain, aiming to suppress its oncogenic functions as a potential anticancer therapeutic strategy.