WSB2

WSB2, WD repeat and SOCS box containing 2, is a protein derived from specific gene expression, featuring WD repeat sequences and a SOCS box. As a substrate recognition component of the CRL5 E3 ubiquitin ligase complex, WSB2 engages in protein ubiquitination and degradation, modulating processes such as apoptosis, proliferation, and oncogenesis. Elevated WSB2 expression is observed in various cancers, where it promotes cell proliferation and tumor growth, and it shows a strong synergistic lethal effect with certain anti-apoptotic proteins, presenting a new target for cancer treatment. Research on WSB2 deepens our understanding of the molecular mechanisms underlying apoptosis and tumorigenesis, providing a foundation for developing novel antitumor drugs and therapeutic strategies.

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Recombinant Human WD repeat and SOCS box-containing protein 2 (WSB2)