ZSWIM8

ZSWIM8, known as the zinc finger SWIM domain protein 8, is an essential component of the ubiquitin ligase system found in a variety of organisms. This protein is responsible for promoting the ubiquitination and degradation of specific substrates, such as AGO2, by recognizing and binding to them. In addition, ZSWIM8 plays a pivotal role in regulating intracellular microRNA degradation and gene expression, which has significant implications for cell biology by revealing new pathways for miRNA degradation and enhancing our understanding of gene regulation. Additionally, ZSWIM8 is involved in viral infections and host interactions; certain viruses utilize ZSWIM8 to degrade host antiviral proteins, thus evading immune responses. This dual role underscores the potential importance of ZSWIM8 in both biological research and medical applications.

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Recombinant Human Zinc finger SWIM domain-containing protein KIAA0913 (KIAA0913), partial