MARS Antibody

1. Compound Arg618Cys and Tyr307Cys variants were identified in an infant with syndromic interstitial lung and liver disease. Arg618Cys associated with Charcot-Marie-Tooth disease was inherited from an unaffected father. PMID: 29655802
2. MRS is frequently overexpressed in NSCLC. Moreover, MRS is related to mTORC1 activity and its overexpression is associated with poor clinical outcomes, indicating that it has potential as a putative therapeutic target. PMID: 28679377
3. Genotype-phenotype correlation analysis suggests most of the interstitial lung and liver disease (ILLD), mutations locate in the catalytic domain of MARS. ILLD and Charcot-Marie-Tooth disease, axonal, type 2U might have different disease mechanism. PMID: 28148924
4. analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3 PMID: 26472928
5. identification of a founder mutation in MARS led to the molecular definition of a specific type of pulmonary alveolar proteinosis and will enable carrier screening in the affected community and possibly open new treatment opportunities. PMID: 25913036
6. the association of rare MARS variant with late-onset autosomal dominant Charcot-Marie-Tooth neuropathy PMID: 24354524
7. The F370L and I523T mutations did not affect the association of MARS with the multisynthetase complex. PMID: 24103465
8. Here we present data suggesting that MARS is a very rare novel cause of late-onset CMT2. PMID: 23729695
9. Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress. PMID: 22106287
10. The last 15 residues of the previously defined N-terminal extension of hcMetRS are part of the catalytic domain, whereas the first 252 residues constitute the N-terminal extended domain. PMID: 19064003

Show More

Hide All

HGNC: 6898

OMIM: 156560

KEGG: hsa:4141

STRING: 9606.ENSP00000262027

UniGene: Hs.632707